The Metabolism & Metabolic Health (M&MH) Core provides phenotyping services for the assessment of metabolic physiology in mouse models relevant to obesity, diabetes, and cardiometabolic health.   The Core offers users the expertise, technical resources, and instrumentation necessary to characterize perturbations in endocrine systems, bioenergetics, and metabolism.   The Core performs assays and data interpretation for in vivo phenotyping including metabolic rate and whole-body substrate utilization, glucose tolerance and insulin sensitivity, systemic metabolomics, hepatic triglyceride production, microbiota metabolism (xenometabolomics) and microbiome characterization, in vivo imaging and body composition, food intake behaviors including food preference, quantitative energy balance measures, and endocrinology. The Core will also give prioritized and subsidized support, training, and consultation to VIBRANT-eligible researchers. The Core is led by Sean H. Adams, PhD, and Co-led by Peter J. Havel, DVM, PhD, with coordination and expertise from Michael Goodson, PhD and Douglas Rowland, PhD. The Core also includes scientific consultants in bioenergetics (Jon Ramsey), metabolomics and xenometabolomics (Oliver Fiehn, Trina Knotts, Brian Piccolo), and continuous glucose monitoring (Mark Huising). James Graham and Todd Tolentino are the Core’s expert technical staff.