The goal of the Physiology and Behavior (P&B) Core is to advance the understanding of behavioral manifestations and pathophysiological mechanisms and systemic consequences of diabetes, obesity, and related metabolic disorders. The Core provides investigators with a range of phenotyping tests and services for the in vivo characterization of ocular, kidney, cardiovascular, and gastrointestinal functions in mouse models of obesity and diabetes. The Core also offers tests that allow investigators to study manifestations of peripheral neuropathy (nociception, gait & ambulation, and wound healing), a common complication of diabetes. Another important component of this Core is to understand how obesity and metabolic disorders influence executive and neurophysiological functions. For this, the Core offers a battery of behavioral (learning, memory, sociability, and anxiety) and neuromotor (gait, ambulation, force) tests to comprehensively interrogate the multifaceted behavioral domains. This Core also has expertise in evaluating exercise and sleep activities. The Core can assist investigators in all steps of the research process, from designing experiments to analyzing and interpreting data. The Core will also give prioritized and subsidized support, training, and consultation to VIBRANT-eligible researchers. The Core is led by Jill L Silverman PhD and Co-led by Louise Lanoue PhD. The Core also includes scientific consultants in ophthalmology (Morshiri Ala MD, PhD), cardiology (Nipivan Chiamvimovat MD), renal function (Maryam Afkarian MD, PhD) and wound healing (Scott Simon PhD). Todd Tolentino and Jody Findley are the Core’s expert technical staff.