
Applying Mouse Biology to Reveal New Insights into Mechanisms of Metabolic Disease
The mission of the Mouse Metabolic Phenotyping Center (MMPC)-Live at UC Davis is to advance medical and biological research on the heterogeneity, pathogenesis, and metabolic and physiologic consequences of diabetes, obesity, and related metabolic diseases by providing the scientific community with complex metabolic, physiologic and behavioral phenotyping and consulting services to characterize living mouse models on a fee-for-service basis.
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Mutant Mouse Resource and Research Center (at UC Davis)
International Mouse Phenotyping Consortium
Our Goals:
- Broaden the scope of metabolic phenotyping tests for mice available to investigators.
- Standardize key methodologies.
- Expedite the completion of research.
- Compile a database of information relevant to mouse models of diabetes, obesity, and diabetic complication
Translational research in vivo using genetic, surgical, humanized, and other types of mouse models are needed to decipher the heterogeneity of diabetes, obesity, and related metabolic disorders. To address this need, UC Davis has established a Mouse Metabolic Phenotyping Center (MMPC)Live as part of the NIH/NIDDK funded MMPCLive National Consortium. The MMPCLive Center at UC Davis provides researchers with specialized and advanced resources to assess mouse models of diabetes and obesity using unique and complex tests and procedures. Researchers have access to experienced scientific and technical experts for consultation and advice on experimental design, test selection, outcomes measures, and data interpretation. Center staff have extensive experience providing in vivo services to produce and analyze live mice for diabetes and obesity research. The Center has robust infrastructure to offer many novel and innovative approaches to provide the research community with high quality metabolic, physiologic, and behavioral phenotyping services in vivo to characterize the etiology, pathogenesis, and consequences of diabetes, obesity, and related metabolic disorders. The Center consists of an Administrative Core, Animal Care Core, and two in vivo phenotyping cores that offer metabolic (The Metabolism and Metabolic Health Core) and behavioral (The Physiology and Behavior Core) phenotyping. Services are offered at reasonable cost to academic and commercial researchers.
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Financial support for this work was provided by the Mouse Metabolic Phenotyping Center (MMPC)Live at UC Davis (MMPCLive, RRID:SCR_015357, mmpc.ucdavis.edu) under the MMPCLive Program, NIH/NIDDK Grant #U2CDK135074.